Document 0549
 DOCN  M9480549
 TI    A new look at HIV transmission from seropositive mothers to their
       infants: the facts beyond serology.
 DT    9410
 AU    Jehuda-Cohen T; Pediatric Research Unit, Rappaport Faculty of Medicine,;
       Technion-Israel Institute of Technology, Haifa, Israel.
 SO    Isr J Med Sci. 1994 May-Jun;30(5-6):364-8. Unique Identifier : AIDSLINE
       MED/94307914
 AB    Once the curtain of maternal antibodies is removed (12-18 months) only a
       fraction of the infants are seropositive. Some babies from whom virus
       has been isolated or detected in their cells subsequently become
       seronegative. What does the negative serology of these children really
       tell us about exposure to HIV? It is suggested that seroconverting is
       only one of the ways to respond to an HIV exposure from an infected
       mother; it is not the only or the best way. Some form of tolerance to
       HIV, emerging after in utero exposure of the fetus, could theoretically
       lead to a seronegative state despite infection. Based on monkey studies
       with simian immunodeficiency virus (SIV), this tolerance could offer
       protection against pathological outcome of the infection. Seronegative
       yet infected/exposed children of HIV-positive mothers exist, though
       their number remains unknown. They might hold the key to a protective
       immunity to HIV.
 DE    Animal  Cercocebus atys  Female  Human  HIV Antibodies/IMMUNOLOGY  HIV
       Infections/EPIDEMIOLOGY/*TRANSMISSION  HIV Seropositivity/*IMMUNOLOGY
       Infant  Infant, Newborn  Israel/EPIDEMIOLOGY  Macaca mulatta  Pregnancy
       Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY/TRANSMISSION
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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